Article
Human estrogen receptor alpha gene is a target of Runx2 transcription factor in osteoblasts.
Experimental cell research - 1 May 2007
Lambertini Elisabetta, Penolazzi Letizia, Tavanti Elisa, Schincaglia Gian Pietro, Zennaro Margherita, Gambari Roberto, Piva Roberta
Abstract excerpt
Several studies into the mechanisms involved in control of osteoblast-specific gene expression have identified Runx2 and ERalpha (estrogen receptor alpha) as essential regulators of osteoblast differentiation. Recently, interactions between Runx2 and ERalpha have been described. Here, we investigate the role of Runx2 on the regulation of ERalpha expression by determining its interaction with the F promoter, one...
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