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Variable osteogenic performance of MC3T3-E1 subclones impacts their utility as models of osteoblast biology

5 Jun 2019

Abstract excerpt

The spontaneously immortalized murine calvarial cell line MC3T3-E1 and its derivative subclones are widely used models of osteoblast biology. Many investigators have reported conflicting data under seemingly similar experimental conditions, though the specific subclone studied is often not specified. The purpose of this study was to directly compare the commercially available MC3T3-E1 subclones 4, 14, and 24 in...

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PMID: 31165768
DOI: 10.1038/s41598-019-44575-8

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