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Article

Runx2 Integrates Estrogen Activity in Osteoblasts

1 Oct 2003

Abstract excerpt

Steroids significantly effect skeletal integrity. For example, bone mass decreases with glucocorticoid excess or with estrogen depletion after menopause. Glucocorticoid suppresses gene expression by an essential skeletal tissue transcription factor, Runx2, in rat osteoblasts. We now report that estrogen enhances Runx2 activity in dose- and estrogen receptor-dependent ways independently of changes in Runx2 levels...

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Identifiers

PMID: 12951324
DOI: 10.1074/jbc.m306531200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Runx2 Integrates Estrogen Activity in OsteoblastsPMID 12951324Read ↗

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Genomic occupancy of Runx2 with global expression profiling identifies a novel dimension to control of osteoblastogenesisSemantic proximity Read ↗

Glucocorticoids Hijack Runx2 to StimulateWif1for Suppression of Osteoblast Growth and DifferentiationSemantic proximity Read ↗

Runx2/Cbfa1 Functions: Diverse Regulation of Gene Transcription by Chromatin Remodeling and Co-Regulatory Protein InteractionsSemantic proximity Read ↗

The Gene for Aromatase, a Rate-Limiting Enzyme for Local Estrogen Biosynthesis, Is a Downstream Target Gene of Runx2 in Skeletal TissuesSemantic proximity Read ↗

Runx2/Cbfa1: A Multifunctional Regulator of Bone FormationSemantic proximity Read ↗

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