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Article

The crystal structure of the carboxy-terminal domain of human translation initiation factor eIF5.

Journal of molecular biology - 7 Jul 2006

Bieniossek Christoph, Schütz Patrick, Bumann Mario, Limacher Andreas, Uson Isabel, Baumann Ulrich

Abstract excerpt

The carboxy-terminal domain (CTD) of eukaryotic initiation factor 5 (eIF5) plays a central role in the formation of the multifactor complex (MFC), an important intermediate for the 43 S pre-initiation complex assembly. The IF5-CTD interacts directly with the translation initiation factors eIF1, eIF2-beta, and eIF3c, thus forming together with eIF2 bound Met-tRNA(i)(Met) the MFC. In this work we present the high...

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Identifiers

PMID: 16781736
DOI: 10.1016/j.jmb.2006.05.021

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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