Article
Glucocerebrosidase mutations are not found in association with LRRK2 G2019S in subjects with parkinsonism.
Neuroscience letters - 14 Aug 2006
Eblan Michael J, Scholz Sonja, Stubblefield Barbara, Gutti Usha, Goker-Alpan Ozlem, Hruska Kathleen S, Singleton Andrew B, Sidransky Ellen
Abstract excerpt
Alteration G2019S in the leucine-rich repeat kinase 2 gene (LRRK2) has been identified in several populations of patients with parkinsonism, including Ashkenazi Jewish subjects with Parkinson disease. Mutations in glucocerebrosidase (GBA), the enzyme deficient in Gaucher disease, are also identified at an increased frequency among Parkinson probands, including those of Ashkenazi Jewish ancestry. A Taqman...
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