Article
Pilot association study of the beta-glucocerebrosidase N370S allele and Parkinson's disease in subjects of Jewish ethnicity.
Movement disorders : official journal of the Movement Disorder Society - 1 Jan 2005
Clark Lorraine N, Nicolai Angelique, Afridi Shehla, Harris Juliette, Mejia-Santana Helen, Strug Lisa, Cote Lucien J, Louis Elan D, Andrews Howard, Waters Cheryl, Ford Blair, Frucht Steven, Fahn Stanley, Mayeux Richard, Ottman Ruth, Marder K
Abstract excerpt
Mutations in the beta-glucocerebrosidase gene cause Gaucher's disease, one of the most common lysosomal lipid storage diseases in the Ashkenazi Jewish population. The occurrence of parkinsonism in patients with Type 1 Gaucher's disease has been noted previously. In this pilot study, we evaluated a possible association between Parkinson's disease (PD) and the beta-glucocerebrosidase gene N370S allele (nt.1226 A>G)...
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