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Article

Mutations in the glucocerebrosidase gene are associated with early-onset Parkinson disease.

Neurology - 18 Sept 2007

Clark L N, Ross B M, Wang Y, Mejia-Santana H, Harris J, Louis E D, Cote L J, Andrews H, Fahn S, Waters C, Ford B, Frucht S, Ottman R, Marder K

Abstract excerpt

OBJECTIVE: To evaluate the frequency of glucocerebrosidase (GBA) mutations in cases and controls enrolled in the Genetic Epidemiology of Parkinson's Disease (GEPD) study. METHODS: We sequenced all exons of the GBA gene in 278 Parkinson disease (PD) cases and 179 controls enrolled in GEPD, with a wide range of age at onset (AAO), and that included a subset of 178 Jewish cases and 85 Jewish controls. Cases and...

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Identifiers

PMID: 17875915
DOI: 10.1212/01.wnl.0000276989.17578.02
PMCID: PMC3624967

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Source receipt: pubmed, retrieved 7 Sept 2026.

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