Article
Multicenter analysis of glucocerebrosidase mutations in Parkinson's disease.
The New England journal of medicine - 22 Oct 2009
Sidransky E, Nalls M A, Aasly J O, Aharon-Peretz J, Annesi G, Barbosa E R, Bar-Shira A, Berg D, Bras J, Brice A, Chen C-M, Clark L N, Condroyer C, De Marco E V, Dürr A, Eblan M J, Fahn S, Farrer M J, Fung H-C, Gan-Or Z, Gasser T, Gershoni-Baruch R, Giladi N, Griffith A, Gurevich T, Januario C, Kropp P, Lang A E, Lee-Chen G-J, Lesage S, Marder K, Mata I F, Mirelman A, Mitsui J, Mizuta I, Nicoletti G, Oliveira C, Ottman R, Orr-Urtreger A, Pereira L V, Quattrone A, Rogaeva E, Rolfs A, Rosenbaum H, Rozenberg R, Samii A, Samaddar T, Schulte C, Sharma M, Singleton A, Spitz M, Tan E-K, Tayebi N, Toda T, Troiano A R, Tsuji S, Wittstock M, Wolfsberg T G, Wu Y-R, Zabetian C P, Zhao Y, Ziegler S G
Abstract excerpt
BACKGROUND: Recent studies indicate an increased frequency of mutations in the gene encoding glucocerebrosidase (GBA), a deficiency of which causes Gaucher's disease, among patients with Parkinson's disease. We aimed to ascertain the frequency of GBA mutations in an ethnically diverse group of patients with Parkinson's disease. METHODS: Sixteen centers participated in our international, collaborative study: five...
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