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Article

Mutational analysis of the Drosophila homothorax gene.

Genetics - 1 Feb 2001

Kurant E, Eytan D, Salzberg A

Abstract excerpt

The homothorax (hth) gene is involved in multiple aspects of embryonic and adult fly development. It encodes a homeodomain-containing protein of the MEIS family and was shown to regulate the subcellular localization of the homeotic protein cofactor Extradenticle (EXD). The HTH protein contains a TALE class homeodomain and a conserved MH domain, which is required for its interaction with EXD. In this work, we...

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Identifiers

PMID: 11156989
DOI: 10.1093/genetics/157.2.689
PMCID: PMC1461517

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Mutational analysis of the Drosophila homothorax gene.PMID 11156989Read ↗

The Homothorax homeoprotein activates the nuclear localization of another homeoprotein, extradenticle, and suppresses eye development in Drosophila.Semantic proximity Read ↗

Distinct functions of homeodomain-containing and homeodomain-less isoforms encoded by homothorax.Semantic proximity Read ↗

Dorsotonals/homothorax, the Drosophila homologue of meis1, interacts with extradenticle in patterning of the embryonic PNS.Semantic proximity Read ↗

Genetic evidence for the transcriptional-activating function of Homothorax during adult fly development.Semantic proximity Read ↗

Roles of the Homothorax/Meis/Prep homolog UNC-62 and the Exd/Pbx homologs CEH-20 and CEH-40 in C. elegans embryogenesis.Semantic proximity Read ↗

TALE-class homeodomain transcription factors, homothorax and extradenticle, control dendritic and axonal targeting of olfactory projection neurons in the Drosophila brain.Semantic proximity Read ↗

Engrailed cooperates with extradenticle and homothorax to repress target genes in Drosophila.Semantic proximity Read ↗

Transcriptional repression of Hox genes by C. elegans HP1/HPL and H1/HIS-24.Semantic proximity Read ↗

Homeodomain-interacting protein kinase (Hipk) is required for nervous system and muscle structure and functionSemantic proximity Read ↗

extradenticle determines segmental identities throughout Drosophila development.Semantic proximity Read ↗

The TALE transcription factor homothorax functions to assemble heterochromatin during Drosophila embryogenesis.Semantic proximity Read ↗

Opposing interactions between homothorax and Lobe define the ventral eye margin of Drosophila eye.Semantic proximity Read ↗

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