Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Engrailed cooperates with extradenticle and homothorax to repress target genes in Drosophila.

Development (Cambridge, England) - 1 Feb 2003

Kobayashi Masatomo, Fujioka Miki, Tolkunova Elena N, Deka Deepali, Abu-Shaar Muna, Mann Richard S, Jaynes James B

Abstract excerpt

Engrailed is a key transcriptional regulator in the nervous system and in the maintenance of developmental boundaries in Drosophila, and its vertebrate homologs regulate brain and limb development. Here, we show that the functions of both of the Hox cofactors Extradenticle and Homothorax play essential roles in repression by Engrailed. Mutations that remove either of them abrogate the ability of Engrailed to...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Body Patterning
Share to Drosophila

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Embryo, Nonmammalian

Share to Homeodomain Proteins

Share to Insect Proteins

Share to Proto-Oncogene Proteins

Share to Wnt1 Protein

Source

Open in PubMed Open full text

Identifiers

PMID: 12506004
DOI: 10.1242/dev.00289
PMCID: PMC2692026

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Engrailed cooperates with extradenticle and homothorax to repress target genes in Drosophila.PMID 12506004Read ↗

The Homothorax homeoprotein activates the nuclear localization of another homeoprotein, extradenticle, and suppresses eye development in Drosophila.Semantic proximity Read ↗

Hox repression of a target gene: extradenticle-independent, additive action through multiple monomer binding sites.Semantic proximity Read ↗

Distinct functions of homeodomain-containing and homeodomain-less isoforms encoded by homothorax.Semantic proximity Read ↗

Dorsotonals/homothorax, the Drosophila homologue of meis1, interacts with extradenticle in patterning of the embryonic PNS.Semantic proximity Read ↗

TALE-class homeodomain transcription factors, homothorax and extradenticle, control dendritic and axonal targeting of olfactory projection neurons in the Drosophila brain.Semantic proximity Read ↗

Control of Drosophila adult pattern by extradenticle.Semantic proximity Read ↗

extradenticle determines segmental identities throughout Drosophila development.Semantic proximity Read ↗

Requirements for transcriptional repression and activation by Engrailed in Drosophila embryos.Semantic proximity Read ↗

dbx mediates neuronal specification and differentiation through cross-repressive, lineage-specific interactions with eve and hb9.Semantic proximity Read ↗

Mutational analysis of the Drosophila homothorax gene.Semantic proximity Read ↗

The role of Polycomb-group response elements in regulation of engrailed transcription in Drosophila.Semantic proximity Read ↗

Opposing interactions between homothorax and Lobe define the ventral eye margin of Drosophila eye.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.