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Article

Distinct functions of homothorax in leg development in Drosophila.

Mechanisms of development - 1 Nov 2002

Azpiazu Natalia, Morata Ginés

Abstract excerpt

The Drosophila leg is subdivided into two mutually antagonistic proximal and distal domains. The proximal domain is defined by the activity of the homeobox genes homothorax and extradenticle and the distal one by the Dpp/Wg targets Distal-less (Dll) and dachshund (dac). It is known that hth/exd function prevents the activity of Dpp and Wg response genes and that cells deficient for exd activity in the proximal...

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PMID: 12385754
DOI: 10.1016/s0925-4773(02)00295-2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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