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Article

Insight into the PrPC-->PrPSc conversion from the structures of antibody-bound ovine prion scrapie-susceptibility variants.

Proceedings of the National Academy of Sciences of the United States of America - 13 Jul 2004

Eghiaian Frédéric, Grosclaude Jeanne, Lesceu Stéphanie, Debey Pascale, Doublet Bénédicte, Tréguer Eric, Rezaei Human, Knossow Marcel

Abstract excerpt

Prion diseases are associated with the conversion of the alpha-helix rich prion protein (PrPC) into a beta-structure-rich insoluble conformer (PrPSc) that is thought to be infectious. The mechanism for the PrPC-->PrPSc conversion and its relationship with the pathological effects of prion diseases are poorly understood, partly because of our limited knowledge of the structure of PrPSc. In particular, the way in...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 15240887
DOI: 10.1073/pnas.0400014101
PMCID: PMC478560

Genes

PRNP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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