Article
Structural and functional role of bases 32 and 33 in the anticodon loop of yeast mitochondrial tRNAIle.
RNA (New York, N.Y.) - 1 Nov 2011
Montanari Arianna, De Luca Cristina, Di Micco Patrizio, Morea Veronica, Frontali Laura, Francisci Silvia
Abstract excerpt
Previous work has demonstrated the usefulness of the yeast model to investigate the molecular mechanisms underlying defects due to base substitutions in mitochondrial tRNA genes, and to identify suppressing molecules endowed with potential clinical relevance. The present paper extends these investigations to two human equivalent yeast mutations located at positions 32 and 33 in the anticodon loop of tRNA(Ile)....
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