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Article

Nuclear DNA-encoded tRNAs targeted into mitochondria can rescue a mitochondrial DNA mutation associated with the MERRF syndrome in cultured human cells.

Human molecular genetics - 15 Oct 2004

Kolesnikova Olga A, Entelis Nina S, Jacquin-Becker Clarisse, Goltzene Francine, Chrzanowska-Lightowlers Zofia M, Lightowlers Robert N, Martin Robert P, Tarassov Ivan

Abstract excerpt

Mitochondrial DNA (mtDNA) mutations are an important cause of human disease for which there is no efficient treatment. Our aim was to determine whether the A8344G mitochondrial tRNA(Lys) mutation, which can cause the MERRF (myoclonic epilepsy with ragged-red fibers) syndrome, could be complemented by targeting tRNAs into mitochondria from the cytosol. Import of small RNAs into mitochondria has been demonstrated...

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PMID: 15317755
DOI: 10.1093/hmg/ddh267

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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