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Article

Analysis of the functional consequences of lethal mutations in mitochondrial translational elongation factors.

Biochimica et biophysica acta - 1 Jan 2000

Akama Kenta, Christian Brooke E, Jones Christie N, Ueda Takuya, Takeuchi Nono, Spremulli Linda L

Abstract excerpt

Mammalian mitochondria synthesize a set of thirteen proteins that are essential for energy generation via oxidative phosphorylation. The genes for all of the factors required for synthesis of the mitochondrially encoded proteins are located in the nuclear genome. A number of disease-causing mutations have been identified in these genes. In this manuscript, we have elucidated the mechanisms of translational...

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Identifiers

PMID: 20435138
DOI: 10.1016/j.bbadis.2010.04.003
PMCID: PMC2893280

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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