Article
Additional copies of the mitochondrial Ef-Tu and aspartyl-tRNA synthetase genes can compensate for a mutation affecting the maturation of the mitochondrial tRNAAsp.
Current genetics - 1 Jun 1997
Rinaldi T, Lande R, Bolotin-Fukuhara M, Frontali L
Abstract excerpt
In an attempt to identify new nuclear genes involved in the synthesis and processing of mitochondrial tRNAs, we utilized a multicopy nuclear library to suppress the heat-sensitive phenotype of a Saccharomyces cerevisiae mitochondrial mutant strain. This strain (Ts 932) is defective in the 3'-end...
Topics
- Aspartate-tRNA Ligase
- Blotting, Northern
- Cell Division
- DNA Transposable Elements
- DNA, Mitochondrial
- Fungal Proteins
- Gene Dosage
- Gene Expression Regulation, Fungal
- Mutagenesis
- Mutation
- Oxidoreductases