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Article

Can yeast be used to study mitochondrial diseases? Biolistic tRNA mutants for the analysis of mechanisms and suppressors.

Mitochondrion - 1 Nov 2009

De Luca Cristina, Zhou YouFang, Montanari Arianna, Morea Veronica, Oliva Romina, Besagni Celine, Bolotin-Fukuhara Monique, Frontali Laura, Francisci Silvia

Abstract excerpt

Base substitutions equivalent to those causing human pathologies have been introduced in yeast mitochondrial tRNA genes. These mutants can be utilized as flexible tools to investigate the molecular aspects of mitochondrial diseases and identify correcting genes. We show that for all studied tRNA...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 19631764
DOI: 10.1016/j.mito.2009.07.004

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-19631764-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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