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Article

Silencing of the human microsomal glucose‐6‐phosphate translocase induces glioma cell death: Potential new anticancer target for curcumin

9 Jun 2006

Abstract excerpt

G6P translocase (G6PT) is thought to play a crucial role in transducing intracellular signaling events in brain tumor-derived cancer cells. In this report, we investigated the contribution of G6PT to the control of U-87 brain tumor-derived glioma cell survival using small interfering RNA (siRNA)-mediated suppression of G6PT. Three siRNA constructs were generated and found to suppress up to 91% G6PT gene...

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PMID: 16777101
DOI: 10.1016/j.febslet.2006.05.071

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