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Article

Essential role of TRPC6 channels in G2/M phase transition and development of human glioma.

Journal of the National Cancer Institute - 21 Jul 2010

Ding Xia, He Zhuohao, Zhou Kechun, Cheng Ju, Yao Hailan, Lu Dongliang, Cai Rong, Jin Yening, Dong Bin, Xu Yinghui, Wang Yizheng

Abstract excerpt

BACKGROUND: Patients with glioblastoma multiforme, the most aggressive form of glioma, have a median survival of approximately 12 months. Calcium (Ca(2+)) signaling plays an important role in cell proliferation, and some members of the Ca(2+)-permeable transient receptor potential canonical (TRPC) family of channel proteins have demonstrated a role in the proliferation of many types of cancer cells. In this...

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Source

Identifiers

PMID: 20554944
DOI: 10.1093/jnci/djq217

Genes

TRPC6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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