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GRP78 is overexpressed in glioblastomas and regulates glioma cell growth and apoptosis

11 Apr 2008

Abstract excerpt

We characterized the expression and function of the endoplasmic reticulum protein GRP78 in glial tumors. GRP78 is highly expressed in glioblastomas but not in oligodendrogliomas, and its expression is inversely correlated with median patient survival. Overexpression of GRP78 in glioma cells decreases caspase 7 activation and renders the cells resistant to etoposide- and cisplatin-induced apoptosis, whereas...

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PMID: 18403493
DOI: 10.1215/15228517-2008-006

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