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Article

Cell surface GRP78 regulates BACE2 via lysosome-dependent manner to maintain mesenchymal phenotype of glioma stem cells.

Journal of experimental & clinical cancer research : CR - 7 Jan 2021

Chen Zihang, Wang Huizhi, Zhang Zongpu, Xu Jianye, Qi Yanhua, Xue Hao, Gao Zijie, Zhao Rongrong, Wang Shaobo, Zhang Shouji, Qiu Wei, Guo Xing, Li Gang

Abstract excerpt

BACKGROUND: Glioma stem cells (GSCs) are considered the initial cells of gliomas, contributing to therapeutic resistance. Patient-derived GSCs well recapitulate the heterogeneity of their parent glioma tissues, which can be classified into different subtypes. Likewise, previous works identified GSCs as two distinct subtypes, mesenchymal (MES) and proneural (PN) subtypes, and with general recognition, the MES...

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Identifiers

PMID: 33413577
DOI: 10.1186/s13046-020-01807-4
PMCID: PMC7791784

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