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Article

Geranylgeranyltransferase I promotes human glioma cell growth through Rac1 membrane association and activation.

Journal of molecular neuroscience : MN - 1 Jan 2013

Zhou Xiuping, Qian Jinming, Hua Lei, Shi Qiong, Liu Zhi, Xu Yinfu, Sang Ben, Mo Jianbing, Yu Rutong

Abstract excerpt

Geranylgeranyltransferase I (GGTase-I) is responsible for the posttranslational lipidation of several signaling proteins such as RhoA, Rac1, and Cdc42, which contribute to tumor development and metastasis. However, the role of GGTase-I in the progression of human glioma is largely unknown. Here, we provide the evidence that Rac1 mediates the effects of GGTase-I on the proliferation and apoptosis in human glioma...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 23073905
DOI: 10.1007/s12031-012-9905-3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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