Article
A model-based approach to selection of tag SNPs.
BMC bioinformatics - 15 Jun 2006
Nicolas Pierre, Sun Fengzhu, Li Lei M
Abstract excerpt
BACKGROUND: Single Nucleotide Polymorphisms (SNPs) are the most common type of polymorphisms found in the human genome. Effective genetic association studies require the identification of sets of tag SNPs that capture as much haplotype information as possible. Tag SNP selection is analogous to the problem of data compression in information theory. According to Shannon's framework, the optimal tag set maximizes...
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