Article
Entropy-based SNP selection for genetic association studies.
Human genetics - 1 Dec 2003
Hampe Jochen, Schreiber Stefan, Krawczak Michael
Abstract excerpt
Because of their abundance, density, and ease of practical use, single-nucleotide polymorphisms (SNPs) have become the major source of information for association gene mapping in humans. Sensible strategies for selecting practically useful SNPs are therefore required. Among the factors influencing the mapping utility of a given set of SNPs are (1). their individual diversity, (2). their haplotype structure in the...
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