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Article

A Markov chain model for haplotype assembly from SNP fragments.

Genome informatics. International Conference on Genome Informatics - 1 Jan 2006

Wang Rui-Sheng, Wu Ling-Yun, Zhang Xiang-Sun, Chen Luonan

Abstract excerpt

Single nucleotide polymorphism (SNP) is the most frequent form of human genetic variations and of importance for medical diagnosis and tracking disease genes. A haplotype is a sequence of SNPs from a single copy of a chromosome, and haplotype assembly from SNP fragments is based on DNA fragments with SNPs and the methodology of shotgun sequence assembly. In contrast to conventional combinatorial models which aim...

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PMID: 17503389

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