Article
The conserved AAUAAA hexamer of the poly(A) signal can act alone to trigger a stable decrease in RNA polymerase II transcription velocity.
RNA (New York, N.Y.) - 1 Aug 2006
Nag Anita, Narsinh Kazim, Kazerouninia Amir, Martinson Harold G
Abstract excerpt
In vivo the poly(A) signal not only directs 3'-end processing but also controls the rate and extent of transcription. Thus, upon crossing the poly(A) signal RNA polymerase II first pauses and then terminates. We show that the G/U-rich region of the poly(A) signal, although required for termination in vivo, is not required for poly(A)-dependent pausing either in vivo or in vitro. Consistent with this, neither...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.