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Article

Interaction of initiator proteins with the origin of replication of an IncL/M plasmid.

Plasmid - 1 Sept 2006

Borrell L, Yang J, Pittard A J, Praszkier J

Abstract excerpt

The origin of replication of the IncL/M plasmid pMU604 was analyzed to identify sequences important for binding of initiator proteins and origin activity. A thrice repeated sequence motif 5'-NANCYGCAA-3' was identified as the binding site (RepA box) of the initiator protein, RepA. All three copies of the RepA box were required for in vivo activity and binding of RepA to these boxes appeared to be cooperative. A...

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Source

Identifiers

PMID: 16774786
DOI: 10.1016/j.plasmid.2006.04.002

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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