Interaction of initiator proteins with the origin of replication of an IncL/M plasmid.

doi:10.1016/j.plasmid.2006.04.002

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Article

Interaction of initiator proteins with the origin of replication of an IncL/M plasmid.

Plasmid - 1 Sept 2006

Borrell L, Yang J, Pittard A J, Praszkier J

Abstract excerpt

The origin of replication of the IncL/M plasmid pMU604 was analyzed to identify sequences important for binding of initiator proteins and origin activity. A thrice repeated sequence motif 5'-NANCYGCAA-3' was identified as the binding site (RepA box) of the initiator protein, RepA. All three copies of the RepA box were required for in vivo activity and binding of RepA to these boxes appeared to be cooperative. A...

Topics

Bacterial Proteins
Base Sequence
Binding Sites
Chloramphenicol O-Acetyltransferase
DNA Footprinting
DNA Helicases
DNA Primers
DNA-Binding Proteins
Electrophoretic Mobility Shift Assay
Gene Expression Regulation, Bacterial

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Molecular Sequence Data

Mutation

Plasmids

Replication Origin

Sequence Analysis, DNA

Trans-Activators

Source

Open in PubMed

Identifiers

PMID: 16774786
DOI: 10.1016/j.plasmid.2006.04.002

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