Article
Enrichment in tumor-reactive CD8+ T-lymphocytes by positive selection from the blood and lymph nodes of patients with head and neck cancer.
Cancer research - 1 Aug 1991
Letessier E M, Heo D S, Okarma T, Johnson J T, Herberman R B, Whiteside T L
Abstract excerpt
To study antitumor functions of T-lymphocyte subpopulations in the blood [peripheral blood lymphocytes (PBLs)] and tumor-draining lymph nodes (LNs) of patients (n = 26) with squamous cell carcinoma of the head and neck (SCCHN), antibody-coated devices were used to positively select CD8+ or CD4+ cells. The mean percentage of CD8+ cells captured on antibody-coated flasks from PBLs was 92% and that captured from...
Topics
- Aged
- Aged, 80 and over
- Antigens, Differentiation, T-Lymphocyte
- CD4-Positive T-Lymphocytes
- CD8 Antigens
- Carcinoma, Squamous Cell
- Cell Division
- Cell Separation
- Cells, Cultured
- Cytotoxicity, Immunologic