Article
Neuroblastoma killing properties of Vδ2 and Vδ2-negative γδT cells following expansion by artificial antigen-presenting cells.
Clinical cancer research : an official journal of the American Association for Cancer Research - 15 Nov 2014
Fisher Jonathan P H, Yan Mengyong, Heuijerjans Jennifer, Carter Lisa, Abolhassani Ayda, Frosch Jennifer, Wallace Rebecca, Flutter Barry, Capsomidis Anna, Hubank Mike, Klein Nigel, Callard Robin, Gustafsson Kenth, Anderson John
Abstract excerpt
PURPOSE: The majority of circulating human γδT lymphocytes are of the Vγ9Vδ2 lineage, and have T-cell receptor (TCR) specificity for nonpeptide phosphoantigens. Previous attempts to stimulate and expand these cells have therefore focused on stimulation using ligands of the Vγ9Vδ2 receptor, whereas relatively little is known about variant blood γδT subsets and their potential role in cancer immunotherapy....
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