Article
Characterization of the cytolytic activity of CD4+ and CD8+ tumor-infiltrating lymphocytes in human renal cell carcinoma.
Cancer research - 15 Apr 1990
Finke J H, Rayman P, Alexander J, Edinger M, Tubbs R R, Connelly R, Pontes E, Bukowski R
Abstract excerpt
Previously we showed that IL2 expanded tumor-infiltrating lymphocytes (TILs) from renal cell carcinoma mediated non-major histocompatibility complex-restricted cytotoxicity. Phenotypic analysis showed that cultured TILs were composed mostly of T-lymphocytes with varying numbers of CD4+, CD8+, and...
Topics
- Adult
- Aged
- Antigens, CD
- Antigens, Differentiation, T-Lymphocyte
- CD4 Antigens
- CD8 Antigens
- Carcinoma, Renal Cell
- Cells, Cultured
- Cytotoxicity, Immunologic
- Female
- Humans
- Interleukin-2
- Kidney Neoplasms
- Killer Cells, Lymphokine-Activated
- Male
- Middle Aged
- Phenotype
- T-Lymphocytes