Molecular and functional analysis of PRKAR1A and its locus (17q22-24) in sporadic adrenocortical tumors: 17q losses, somatic mutations, and protein kinase A expression and activity.

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Molecular and functional analysis of PRKAR1A and its locus (17q22-24) in sporadic adrenocortical tumors: 17q losses, somatic mutations, and protein kinase A expression and activity.

Cancer research - 1 Sept 2003

Bertherat Jerome, Groussin Lionel, Sandrini Fabiano, Matyakhina Ludmila, Bei Thalia, Stergiopoulos Sotirios, Papageorgiou Theocharis, Bourdeau Isabelle, Kirschner Lawrence S, Vincent-Dejean Caroline, Perlemoine Karine, Gicquel Christine, Bertagna Xavier, Stratakis Constantine A

Abstract excerpt

Germ-line protein kinase A (PKA) regulatory-subunit type-Ialpha (RIalpha; PRKAR1A)-inactivating mutations and loss-of-heterozygosity (LOH) of its 17q22-24 locus have been found in Cushing syndrome (CS) caused by primary pigmented nodular adrenocortical disease (PPNAD). We examined whether somatic 17q22-24, PRKAR1A, or PKA changes are present in 44 sporadic adrenocortical tumors (29 adenomas and 15 cancers); 26 of...

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PMID: 14500362

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