Article
Allelic loss at 1p is associated with tumor progression of meningiomas.
Genes, chromosomes & cancer - 1 Apr 1994
Bello M J, de Campos J M, Kusak M E, Vaquero J, Sarasa J L, Pestaña A, Rey J A
Abstract excerpt
Next to chromosome 22 anomalies, deletions of the short arm of chromosome 1 have previously been described as the most frequent alteration detected by cytogenetic analysis of meningiomas. To determine the incidence of these deletions, we have analyzed a series of 50 meningiomas for the loss of alleles at four chromosome 1 loci. Thirteen samples displayed LOH for the markers studied; in one instance, the results...
Topics
- Alleles
- Cell Transformation, Neoplastic
- Chromosome Aberrations
- Chromosome Deletion
- Chromosomes, Human, Pair 1
- DNA, Neoplasm
- Gene Deletion
- Humans
- Meningeal Neoplasms
- Meningioma
- Sequence Deletion