Article
Transcriptional regulation of the neuropeptide VGF by the neuron-restrictive silencer factor/neuron-restrictive silencer element.
Neuroreport - 11 Feb 2015
Moon Sung-Min, Kim Jae-Sung, Park Bo Ram, Kim Do Kyung, Kim Su-Gwan, Kim Heung-Joong, Chun Hong Sung, Lee Byung-Kwon, Kim Chun Sung
Abstract excerpt
The neurotrophin-inducible gene VGF plays an important role in the maintenance of organismal energy balance and in the mediation of hippocampal synaptic activity. The regulatory mechanism of VGF transcription is not fully understood. The neuron-restrictive silencer factor (NRSF) binds with the neuron-restrictive silencer element (NRSE), thereby suppressing the transcription of NRSE-containing genes. In this...
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