Article
Association of FXIII Val34Leu with decreased risk of myocardial infarction in Finnish males.
Atherosclerosis - 1 Feb 1999
Wartiovaara U, Perola M, Mikkola H, Tötterman K, Savolainen V, Penttilä A, Grant P J, Tikkanen M J, Vartiainen E, Karhunen P J, Peltonen L, Palotie A
Abstract excerpt
Factor XIII is a transglutaminase that crosslinks fibrin in the last steps of the coagulation process. A few polymorphic sites have been identified in this gene, one of them being a point mutation (FXIII Val34Leu), leading to an amino acid change of valine to leucine. Recently, in British patients, FXIII 34Leu allele was suggested to be associated with a decreased incidence of myocardial infarction (MI). PAI-1...
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