Article
Two distinct domains in pro-region of Nodal-related 3 are essential for BMP inhibition.
Biochemical and biophysical research communications - 28 Jul 2006
Haramoto Yoshikazu, Takahashi Shuji, Asashima Makoto
Abstract excerpt
The transforming growth factor-beta (TGF-beta) superfamily member, Xenopus nodal-related 3 (Xnr3), induces neural tissues through inhibition of bone morphogenetic proteins (BMPs). We recently identified an inhibitory mechanism in which the pro-region of Xenopus tropicalis nodal-related 3 (Xtnr3) physically interacts with BMP ligands. Here, we show that disulfide-linked heterodimerization does not contribute to...
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