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Article

BMP-3 is a novel inhibitor of both activin and BMP-4 signaling in Xenopus embryos.

Developmental biology - 1 Sept 2005

Gamer Laura W, Nove John, Levin Michael, Rosen Vicki

Abstract excerpt

In Xenopus, the biological effects of BMP-3 oppose those of ventralizing BMPs, but the mechanism for this antagonism remains unclear. Here, we demonstrate that BMP-3 is a dorso-anteriorizing factor in Xenopus embryos that interferes with both activin and BMP signaling. BMP-3 acts by binding to ActRIIB, the common type II receptor for these proteins. Once BMP-3 binds to ActRIIB, it cannot be competed off by excess...

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Identifiers

PMID: 16054124
DOI: 10.1016/j.ydbio.2005.06.012

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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