Article
A novel role for a nodal-related protein; Xnr3 regulates convergent extension movements via the FGF receptor.
Development (Cambridge, England) - 1 May 2003
Yokota Chika, Kofron Matt, Zuck Mike, Houston Douglas W, Isaacs Harry, Asashima Makoto, Wylie Chris C, Heasman Janet
Abstract excerpt
Convergent extension behaviour is critical for the formation of the vertebrate body axis. In Xenopus, components of the Wnt signaling pathway have been shown to be required for convergent extension movements but the relationship between cell fate and morphogenesis is little understood. We show by loss of function analysis that Xnr3 activates Xbra expression through FGFR1. We show that eFGF activity is not...
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