Article
SAGA interacting factors confine sub-diffusion of transcribed genes to the nuclear envelope.
Nature - 8 Jun 2006
Cabal Ghislain G, Genovesio Auguste, Rodriguez-Navarro Susana, Zimmer Christophe, Gadal Olivier, Lesne Annick, Buc Henri, Feuerbach-Fournier Frank, Olivo-Marin Jean-Christophe, Hurt Eduard C, Nehrbass Ulf
Abstract excerpt
Changes in the transcriptional state of genes have been correlated with their repositioning within the nuclear space. Tethering reporter genes to the nuclear envelope alone can impose repression and recent reports have shown that, after activation, certain genes can also be found closer to the nuclear periphery. The molecular mechanisms underlying these phenomena have remained elusive. Here, with the use of...
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