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Article

The spleen microenvironment influences disease transformation in a mouse model of KITD816V-dependent myeloproliferative neoplasm.

Scientific reports - 27 Jan 2017

Pelusi Natalie, Kosanke Maike, Riedt Tamara, Rösseler Corinna, Seré Kristin, Li Jin, Gütgemann Ines, Zenke Martin, Janzen Viktor, Schorle Hubert

Abstract excerpt

Activating mutations leading to ligand-independent signaling of the stem cell factor receptor KIT are associated with several hematopoietic malignancies. One of the most common alterations is the D816V mutation. In this study, we characterized mice, which conditionally express the humanized KITD816V receptor in the adult hematopoietic system to determine the pathological consequences of unrestrained KIT signaling...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 28128288
DOI: 10.1038/srep41427
PMCID: PMC5269732

Genes

KIT

Variants

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