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Therapy-induced PML/RARA Proteolysis and Acute Promyelocytic Leukemia Cure

7 Oct 2009

Abstract excerpt

Acute promyelocytic leukemia (APL) is characterized by a specific t(15;17) chromosomal translocation that yields the PML/RARA fusion gene. Clinically, besides chemotherapy, two drugs induce clinical remissions: retinoic acid (RA) and arsenic trioxide (As). Both agents directly target PML/RARA-mediated transcriptional repression and protein stability, inducing to various extent promyelocyte differentiation and...

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PMID: 19808868
DOI: 10.1158/1078-0432.ccr-09-0209

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