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Article

Different effects of clopidogrel and clarithromycin on the enantioselective pharmacokinetics of sibutramine and its active metabolites in healthy subjects.

Journal of clinical pharmacology - 1 May 2013

Shinde Dhananjay D, Kim Ho-Sook, Choi Jae-Seok, Pan Wei, Bae Soo Kyung, Yeo Chang-Woo, Shon Ji-Hong, Kim Dong-Hyun, Shin Jae Gook

Abstract excerpt

In this study, we assessed the effects of clopidogrel and clarithromycin, known CYP2B6 and CYP3A inhibitors, respectively, on the enantioselective disposition of racemic sibutramine in conjunction with CYP2B6 polymorphisms in humans. Sibutramine showed enantioselective plasma profiles with consistently higher concentrations of R-enantiomers. Clopidogrel and clarithromycin significantly increased the sibutramine...

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PMID: 23381968
DOI: 10.1002/jcph.69

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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