Article
Noninvasive identification of interindividual variation in xenobiotic-metabolizing enzymes: implications for cancer epidemiology and biomarker studies.
Journal of toxicology and environmental health. Part A - 1 Jul 2006
Dash B, Afriyie-Gyawu E, Huebner H J, Porter W, Wang J S, Jolly P E, Phillips T D
Abstract excerpt
In this study, DNA extracted from frozen urine was used in the analysis of polymorphisms in genes coding for xenobiotic-metabolizing enzymes (XMEs). These included single-nucleotide polymorphisms (SNP) in microsomal epoxide hydrolase (mEH), that is, substitutions of tyrosine by histidine in codon 113 (Y113H) and histidine by arginine in codon 139 (H139R), and deletion polymorphisms in glutathione S-transferase...
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