Drug-metabolizing enzymes, polymorphisms and interindividual response to environmental toxicants.

doi:10.1515/CCLM.2000.124

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Article

Drug-metabolizing enzymes, polymorphisms and interindividual response to environmental toxicants.

Clinical chemistry and laboratory medicine - 1 Sept 2000

Nebert D W

Abstract excerpt

Individual risk of toxicity or cancer reflects the amount of exposure to environmental agents, combined with one's underlying genetic predisposition. More than six dozen human ecogenetic polymorphisms have been described; whereas some of these have been demonstrated to be associated with altered risks of toxicity or cancer, others presently remain equivocal and require further study. Thus, genetic differences in...

Topics

Animals
Cytochrome P-450 Enzyme System
Environmental Pollutants
Genetic Diseases, Inborn
Genetic Predisposition to Disease
Humans
Neoplasms
Plants
Polymorphism, Genetic
Risk Factors
Transferases

Source

Open in PubMed

Identifiers

PMID: 11097340
DOI: 10.1515/CCLM.2000.124

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