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Article

Variability in human sensitivity to 1,3-butadiene: Influence of the allelic variants of the microsomal epoxide hydrolase gene.

Environmental and molecular mutagenesis - 1 Jan 2003

Abdel-Rahman Sherif Z, El-Zein Randa A, Ammenheuser Marinel M, Yang Zhen, Stock Thomas H, Morandi Maria, Ward Jonathan B

Abstract excerpt

The carcinogenic effects of 1,3-butadiene (BD), a chemical widely used in the rubber industry, are thought to be due to its epoxide metabolites. In humans, these epoxides are detoxified predominantly by hydrolysis, a reaction mediated by the microsomal epoxide hydrolase (mEH) enzyme. The mEH gene is polymorphic and the most common mEH coding-region variants detected in human populations are the two amino acid...

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PMID: 12605384
DOI: 10.1002/em.10142

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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Variability in human sensitivity to 1,3-butadiene: Influence of the allelic variants of the microsomal epoxide hydrolase gene.PMID 12605384Read ↗

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