Article
Natural killer cell differentiation driven by Tyro3 receptor tyrosine kinases.
Nature immunology - 1 Jul 2006
Caraux Anouk, Lu Qingxian, Fernandez Nadine, Riou Sylvain, Di Santo James P, Raulet David H, Lemke Greg, Roth Claude
Abstract excerpt
Although understanding of the function and specificity of many natural killer (NK) cell receptors is increasing, the molecular mechanisms regulating their expression during late development of NK cells remain unclear. Here we use representational difference analysis to identify molecules required for late NK cell differentiation. Axl protein tyrosine kinase, together with the structurally related receptors Tyro3...
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