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Article

The innate cytokine IL-18 inhibits CNS autoimmunity through preferential activation of protective CD8 T-cells

2026-01-28

Abstract excerpt

Chronic innate immune activation is widely thought to challenge self-tolerance. IL-18 is an inflammasome-activated cytokine and potent amplifier of T-cell activation whose excess is associated with certain autoinflammatory, but not autoimmune, diseases. We tested how excess IL-18 affected susceptibility to experimental autoimmune encephalomyelitis (EAE), a model of CNS autoimmunity driven by IL-18 responsive, myel...

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Literature Corpus work
3b339a40-abdb-5173-9b74-96d5dca07e6b
DOI
10.64898/2026.01.26.701759
Open publication

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