Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Interleukin-18 (IL-18) engineered for half-life extension and resistance to IL-18 binding protein (IL-18BP) to enhance anti-cancer therapeutic potential

21 Jun 2025

Abstract excerpt

Recombinant interleukin-18 (IL-18) holds promise as a therapeutic for oncology, as a robust activator of adaptive and innate immune cells and a potent producer of IFN-γ. However, clinical success has been limited due to rapid upregulation of the natural IL-18 inhibitor, IL-18 binding protein (IL-18BP), and fast systemic clearance of active IL-18, unbound to IL-18BP. To overcome these limitations, human IL-18 and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer Immunotherapy and Biomarkers
Share to Immunotherapy and Immune Responses
Share to Inflammasome and immune disorders

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 40544635
DOI: 10.1016/j.cyto.2025.156979

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Interleukin-18 (IL-18) engineered for half-life extension and resistance to IL-18 binding protein (IL-18BP) to enhance anti-cancer therapeutic potentialPMID 40544635Read ↗

Suppression of multiple mouse models of refractory malignancies by reprogramming IL-18 ligand-receptor interactionSemantic proximity Read ↗

IL-18 and IL-18BP: A Unique Dyad in Health and DiseaseSemantic proximity Read ↗

Interleukin-18 Binding Protein in Immune Regulation and Autoimmune DiseasesSemantic proximity Read ↗

Interleukin‑18 binding protein: Biological properties and roles in human and animal immune regulation (Review)Semantic proximity Read ↗

Designing IL-24-P18 Fusion Protein Through Computational Engineering for Targeted Breast Cancer TherapySemantic proximity Read ↗

<i>First-in-class</i> Transactivator-Free, Doxycycline-inducible IL-18-engineered CAR-T cells for relapsed/refractory B-cell lymphomasSemantic proximity Read ↗

Non-pathogenic E. coli displaying decoy-resistant IL18 mutein boosts anti-tumor and CAR NK cell responsesSemantic proximity Read ↗

First-in-class transactivator-free, doxycycline-inducible IL-18-engineered CAR-T cells for relapsed/refractory B cell lymphomasSemantic proximity Read ↗

A resource of high-quality and versatile nanobodies for drug deliverySemantic proximity Read ↗

Engineering human IL-18 with increased bioactivity and bioavailability.Semantic proximity Read ↗

CAR T Cells Secreting IL18 Augment Antitumor Immunity and Increase T Cell Proliferation and CostimulationSemantic proximity Read ↗

New therapeutic strategies based on biasing IL-2 mutants for cancers and autoimmune diseasesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.