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Article

Two-component bacterial multidrug transporter, EbrAB: Mutations making each component solely functional.

Biochimica et biophysica acta - 1 May 2006

Kikukawa Takashi, Nara Toshifumi, Araiso Tsunehisa, Miyauchi Seiji, Kamo Naoki

Abstract excerpt

EbrAB in Bacillus subtilis belongs to a novel small multidrug resistance (SMR) family of multidrug efflux pumps. EmrE in Escherichia coli, a representative of SMR, functions as a homo-oligomer in the membrane. On the other hand, EbrAB requires a hetero-oligomeric configuration consisting of two polypeptides, EbrA and EbrB. Although both polypeptides have a high sequence similarity, expression of either single...

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PMID: 16750162
DOI: 10.1016/j.bbamem.2006.04.004

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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