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Article

A broad-specificity multidrug efflux pump requiring a pair of homologous SMR-type proteins.

Journal of bacteriology - 1 Apr 2000

Jack D L, Storms M L, Tchieu J H, Paulsen I T, Saier M H

Abstract excerpt

The Bacillus subtilis genome encodes seven homologues of the small multidrug resistance (SMR) family of drug efflux pumps. Six of these homologues are paired in three distinct operons, and coexpression in Escherichia coli of one such operon, ykkCD, but not expression of either ykkC or ykkD alone, gives rise to a broad specificity, multidrug-resistant phenotype including resistance to cationic, anionic, and...

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Identifiers

PMID: 10735877
DOI: 10.1128/JB.182.8.2311-2313.2000
PMCID: PMC111283

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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