Article
Specificity determinants in small multidrug transporters.
Journal of molecular biology - 30 Jan 2015
Brill Shlomo, Sade-Falk Ofir, Elbaz-Alon Yael, Schuldiner Shimon
Abstract excerpt
Multiple-antibiotic resistance has become a major global public health concern, and to overcome this problem, it is necessary to understand the resistance mechanisms that allow survival of the microorganisms at the molecular level. One mechanism responsible for such resistance involves active removal of the antibiotic from the pathogen cell by MDTs (multidrug transporters). A prominent MDT feature is their high...
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